Quinolines and derivatives
Medchemexpress LLC Recombinant mouse interleukin-31 (IL-31) | >85.0% | 50 UG
Recombinant mouse interleukin-31 (IL-31) produced in HEK293 cells with a C-terminal His tag, supplied as a 0.22 μm filtered solution in PBS (pH 7.4). The protein is designed for biochemical and cell-based assays, including receptor binding and signaling studies; manufacturer provides activity, purity, and storage data.
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Supplied in PBS (pH 7.4), 0.22 μm filtered.
- >85.0% purity by reducing SDS-PAGE.
- Approximate molecular weight 17.1 kDa (reducing SDS-PAGE).
- Bioactivity: ED50 ≈ 2.916 μg/mL in receptor-binding ELISA.
- Store long-term at -80°C; avoid repeated freeze-thaw.
Medchemexpress LLC Subtilisin (EC 3.4.21.14) | 9014-01-1 | 200 MG
Subtilisin (EC 3.4.21.14) is a bacterial serine protease produced through deep fermentation, extraction, and purification of *Bacillus subtilis*. It hydrolyzes protein molecules into polypeptides or amino acids and can catalyze polypeptide synthesis in organic solvents. This product contains stabilizers and has observed anticancer and antifouling activities.
- Induces apoptosis
- Stimulates expression of pro-allergic cytokines (IL-1α, IL-33)
- Induces prototypic allergic lung inflammation
- Exhibits anticancer activity against breast and colon cancer
- Shows antifouling activity
- Can be used as a detergent additive
- Effective temperature range: 20-60°C (optimum 35-45°C)
- Effective pH range: 6.0-11.0 (optimum 9.5-10.5)
- Activators: Ca2+, Mg2+, Mn2+, Zn2+, Fe2+
- Inhibitors: Reagents acting on serine such as sulfonyl halides
Medchemexpress LLC Pyrimethanil | 53112-28-0 | 99.9% | 200 MG
Pyrimethanil is an anilinopyrimidine and a broad-spectrum contact fungicide. It is used to control Botrytis species on various crops by inhibiting methionine biosynthesis in Botrytis cinerea. This compound is suitable for research aimed at preventing fungal diseases in fruit, vegetable, and ornamental plants with mold infections.
- Inhibits methionine and other amino acids biosynthesis in Botrytis cinerea.
- Aids research into preventing fungal diseases on fruit, vegetable, and ornamental plants.
- Decreases polygalacturonase, cellulase, proteinase, and laccase activities.
- Molecular weight: 199.25.
- Molecular formula: C12H13N3.
- Appearance: White to off-white solid.
Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G
Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. It has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor
- Enhances gastric contractility and accelerates delayed gastric emptying
- Potential for research of functional dyspepsia and intestinal inflammatory conditions
Medchemexpress LLC Quinidine hydrochloride monohydrate | 6151-40-2 | 99.97% | 100 MG
Quinidine hydrochloride monohydrate is an anti-arrhythmic agent that also acts as a potent blocker of K+ channels. It is intended for research use only.
- Potent K+ channel blocker.
- Aids in electrophysiological research.
- Available in solid and solution forms for various experimental needs.
- Comes with detailed documentation for quality assurance.
- Referenced in numerous scientific publications.
- Offers diverse applications for in vitro and in vivo studies.
- Easily soluble in common laboratory solvents.
- Supports accurate dosage calculations for experimental protocols.
Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.36% | 5 G
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM, and it can induce apoptosis. It can be used for malaria research.
- Antiarrhythmic agent: Helps in the treatment of irregular heartbeats.
- Potent, orally active, selective cytochrome P450db inhibitor: Targets and inhibits specific cytochrome P450 enzymes.
- K+ channel blocker: Blocks potassium channels with an IC50 of 19.9 μM.
- Induces apoptosis: Capable of triggering programmed cell death.
- Used for malaria research: Applicable in studies related to malaria.
Medchemexpress LLC Dihydroethidium | 104821-25-2 | 98.83% | 25 MG
Dihydroethidium, also known as DHE, is a peroxide indicator that penetrates cell membranes to form a fluorescent protein complex with blue fluorescence. After entering cells, it primarily localizes in the cell membrane, cytoplasm, and nucleus, with the strongest staining effect in the nucleus. It produces inherent blue fluorescence and, upon dehydrogenation, combines with RNA or DNA to produce red fluorescence.
- Peroxide indicator
- Penetrates cell membranes
- Forms a fluorescent protein complex with blue fluorescence
- Primarily localized in cell membrane, cytoplasm, and nucleus, strongest staining in the nucleus
- Produces inherent blue fluorescence (Ex 370 nm, Em 420 nm)
- Combines with RNA or DNA after dehydrogenation to produce red fluorescence (Ex 300 nm, Em 610 nm; 535 nm also usable for excitation)
- Solid form
- Pale purple to light pink color
- For research use only
Medchemexpress LLC 2,6-Dimethoxy-1,4-benzoquinone | 530-55-2 | 168.15 | 1 ML
2,6-Dimethoxy-1,4-benzoquinone | 530-55-2 | 168.15 | 1 ML
Medchemexpress LLC Sulfo-Cy3 azide | 1801695-56-6 | MFCD30527437 | 99.6% | 806.97 | C35H46N6O10S3 | 10 MG
Sulfo-Cy3 Azide is a water-soluble Cy3 fluorescent dye bearing an azide functional group for bioorthogonal click chemistry. It is designed for labeling sensitive biomolecules, such as proteins, via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC). The dye exhibits excitation/emission around 550/570 nm and is supplied in research pack sizes.
- Water-soluble cyanine dye suitable for aqueous labeling reactions.
- Azide functional group enables CuAAC and SPAAC click chemistry.
- Excitation/emission approximately 550/570 nm for bright fluorescence.
- Soluble in DMSO at 50 mg/mL (requires sonication; use fresh DMSO).
- High purity suitable for research applications.
Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG
Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.98% | 10 MM 1 ML
Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It also acts as a potent alpha1-adrenergic receptor antagonist and a NUPR1 inhibitor, exhibiting anticancer activity. Furthermore, it is identified as a calmodulin inhibitor and an inhibitor of P-glycoprotein. This compound is suitable for research related to schizophrenia and has been observed to act as a reversible inhibitor of influenza virus morphogenesis.
- Antipsychotic agent
- Blocks central dopamine receptors
- Potent alpha1-adrenergic receptor antagonist
- Potent NUPR1 inhibitor
- Exhibits anticancer activity
- Calmodulin inhibitor
- Inhibitor of P-glycoprotein
- Suitable for research related to schizophrenia
- Reversible inhibitor of influenza virus morphogenesis
Medchemexpress LLC N-(1-phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine | 662163-81-7 | MFCD04077630 | 99.9% | 318.42 g·mol^-1 | C20H22N4 | 200 MG
Importazole is a small-molecule inhibitor of the nuclear transport receptor importin-β used in laboratory research to selectively block importin-β-mediated nuclear import. It is supplied as a white to off-white solid with documented solubility and storage recommendations for reliable use in cell biology studies. For research use only.
- Selective inhibitor of importin-β.
- High purity, typically about 99.9%.
- White to off-white solid form.
- Soluble in DMSO; in vitro and in vivo formulation protocols available.
- Stable under recommended storage conditions for powder and solutions.
- Intended for research use only; not for therapeutic use.
Medchemexpress LLC 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide | 909089-13-0 | MFCD14733081 | 99.7% | 286.29 g/mol | C14H14N4O3 | 200 MG
SKL2001 is a small-molecule agonist of the Wnt/β-catenin signaling pathway used in biomedical research. It stabilizes intracellular β-catenin by disrupting the Axin/β-catenin interaction and has reported anti-cancer activity. The compound is supplied as a high-purity solid and exhibits high solubility in DMSO, with available protocols for in vivo formulation.
eMolecules 4-Hydroxyquinoline-2-carboxylic acid hydrate | 345909-35-5 | MFCD00149476 | 1g
Apollo Scientific | 4-Hydroxyquinoline-2-carboxylic acid hydrate | 1g | 562444254 | OR12784 | | 345909-35-5 | MFCD00149476 | 207.185 | C10H9NO4
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